New opportunities with true 3D microfluidics

Advances in Two-Photon Polymerization allow to create not only 2D and 2.5D microchannel structures but also nearly any 3D object inside an open or even sealed microchannel. Explore Nanoscribe’s 3D Microfabrication solutions for rapid prototyping or fabrication of truly high-precision microfluidic systems.

Microchannel mastering and in-chip printing for microfluidic devices

Various 2.5D and 3D microfluidic elements such as nozzles, filters, mixers and capillary pumps become feasible thanks to the advanced 3D Microfabrication capabilities of Nanoscribe systems. Tailored topographies and smooth surfaces can be produced with high definition. Also sharp micro-needle arrays can be created to control small quantities of liquids, e.g., for precise drug delivery.

Our 3D printers offer the highest resolution for additive manufacturing available on the market, achieving minimal feature sizes in the submicron range. The additive approach allows to fabricate microchannel master molds in 2D and 2.5D and to directly print complex microfluidic 3D structures, such as a filigree microfluidic mixer, even in fully sealed microchannels.

For example, mastering and in-chip 3D printing are combined to miniaturize a wet-spinning process in a microfluidic chip: First, a positive master of the microfluidic channel system is printed. Then, by casting PDMS over the printed channels, a negative mold of the channel structures is fabricated. This PDMS slab is sealed by adhering it to a microscope slide using oxygen plasma. The channels are then filled with photoresin, followed by an in-chip 3D printing step. Using Two-Photon Polymerization and an objective lens to focus the laser beam inside the channel, a 3D micronozzle is printed.

application opportunities

You want to assess the opportunities for your project in microfluidics? Explore the application options of our 3D Microfabrication solutions. Have a look at the 10 most recent scientific publications in microfluidics.
To view the details of the publications and to find more research topics and applications in which Nanoscribe 2PP-based 3D printing systems are already successfully used, just enter our premium resources – log in or register for free.


Non-symmetric pinning of topological defects in living liquid crystals


Reduced rotational flows enable the translation of surface-rolling microrobots in confined spaces


Influence of the gas viscosity on the stability of flow focusing


Horseshoe lamination mixer (HLM) sets new standards in the production of monodisperse lipid nanoparticles


An addressable electrowetting valve for centrifugal microfluidics


Unexpected stability of micrometer weakly viscoelastic jets


Engineering a living cardiac pump on a chip using high-precision fabrication


Multiphoton Nanosculpting of Optical Resonant and Nonresonant Microsensors on Fiber Tips


Wet metallization of 3D printed microarchitectures Application to the manufacturing of bioinspired microswimmers


Water as a “glue” Elasticity-enhanced wet attachment of biomimetic microcup structures

View more innovation projects

You get more publication examples and deeper insights within our premium resources. Via a keyword-underpinned database you find more than 1,400 scientific publications of our customers in specific application areas. Make use of the tool to gather valuable know-how and background information about the manifold application options.

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